Article
Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length.
International journal of cancer - 1 Mar 2015
Campa Daniele, Martino Alessandro, Varkonyi Judit, Lesueur Fabienne, Jamroziak Krzysztof, Landi Stefano, Jurczyszyn Artur, Marques Herlander, Andersen Vibeke, Jurado Manuel, Brenner Hermann, Petrini Mario, Vogel Ulla, García-Sanz Ramón, Buda Gabriele, Gemignani Federica, Ríos Rafael, Vangsted Annette Juul, Dumontet Charles, Martínez-López Joaquín, Moreno María José, Stępień Anna, Wątek Marzena, Moreno Victor, Dieffenbach Aida Karina, Rossi Anna Maria, Butterbach Katja, Jacobsen Svend E Hove, Goldschmidt Hartmut, Sainz Juan, Hillengass Jens, Orciuolo Enrico, Dudziński Marek, Weinhold Niels, Reis Rui Manuel, Canzian Federico
Abstract excerpt
Compelling biological and epidemiological evidences point to a key role of genetic variants of the TERT and TERC genes in cancer development. We analyzed the genetic variability of these two gene regions using samples of 2,267 multiple myeloma (MM) cases and 2,796 healthy controls. We found that a TERT variant, rs2242652, is associated with reduced MM susceptibility (OR = 0.81; 95% CI: 0.72-0.92; p = 0.001). In...
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