Article
Genetically determined telomere length and multiple myeloma risk and outcome.
Blood cancer journal - 14 Apr 2021
Giaccherini Matteo, Macauda Angelica, Orciuolo Enrico, Rymko Marcin, Gruenpeter Karolina, Dumontet Charles, Raźny Malgorzata, Moreno Victor, Buda Gabriele, Beider Katia, Varkonyi Judit, Avet-Loiseau Hervé, Martinez-Lopez Joaquín, Marques Herlander, Watek Marzena, Sarasquete Maria Eugenia, Andersen Vibeke, Karlin Lionel, Suska Anna, Kruszewski Marcin, Abildgaard Niels, Dudziński Marek, Butrym Aleksandra, Nagler Arnold, Vangsted Annette Juul, Kadar Katalin, Waldemar Tomczak, Jamroziak Krzysztof, Jacobsen Svend Erik Hove, Ebbesen Lene Hyldahl, Taszner Michał, Mazur Grzegorz, Lesueur Fabienne, Pelosini Matteo, Garcia-Sanz Ramon, Jurczyszyn Artur, Demangel Delphine, Reis Rui Manuel, Iskierka-Jażdżewska Elżbieta, Markiewicz Miroslaw, Gemignani Federica, Subocz Edyta, Zawirska Daria, Druzd-Sitek Agnieszka, Stępień Anna, Alonso M Henar, Sainz Juan, Canzian Federico, Campa Daniele
Abstract excerpt
Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured in leukocytes (LTL) has been investigated in different cancer types, including multiple myeloma (MM). However, LTL measurement is prone to heterogeneity due to sample handling and study design (retrospective vs. prospective). LTL is genetically determined; genome-wide...
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