Article
Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms.
Blood cancer journal - 1 Sept 2020
Giaccherini Matteo, Macauda Angelica, Sgherza Nicola, Sainz Juan, Gemignani Federica, Maldonado Josè Manuel Sanchez, Jurado Manuel, Tavano Francesca, Mazur Grzegorz, Jerez Andrés, Góra-Tybor Joanna, Gołos Aleksandra, Mohedo Francisca Hernández, Lopez Joaquin Martinez, Várkonyi Judit, Spadano Raffaele, Butrym Aleksandra, Canzian Federico, Campa Daniele
Abstract excerpt
Telomere length measured in leukocyte (LTL) has been found to be associated with the risk of developing several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at least, 11 SNPs previously shown to influence LTL. Their combination in a score has been used as a genetic instrument to measure LTL and evaluate the causative association between LTL and the risk of several...
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