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Article

Search for multiple myeloma risk factors using Mendelian randomization.

Blood advances - 26 May 2020

Went Molly, Cornish Alex J, Law Philip J, Kinnersley Ben, van Duin Mark, Weinhold Niels, Försti Asta, Hansson Markus, Sonneveld Pieter, Goldschmidt Hartmut, Morgan Gareth J, Hemminki Kari, Nilsson Björn, Kaiser Martin, Houlston Richard S

Abstract excerpt

The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS of 7717 MM cases...

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Identifiers

PMID: 32433745
DOI: 10.1182/bloodadvances.2020001502
PMCID: PMC7252541

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