Article
Telomere length and hTERT genetic variants as potential prognostic markers in multiple myeloma.
Scientific reports - 22 Sept 2023
Dratwa Marta, Łacina Piotr, Butrym Aleksandra, Porzuczek Diana, Mazur Grzegorz, Bogunia-Kubik Katarzyna
Abstract excerpt
Telomere dysfunction is a notable event observed in many cancers contributing to their genomic instability. A major factor controlling telomere stability is the human telomerase reverse transcriptase catalytic subunit (hTERT). Telomere shortening has been observed in multiple myeloma (MM), a plasma cell malignancy with a complex and heterogeneous genetic background. In the present study, we aimed to analyse...
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