Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.

doi:10.1002/dvdy.20996

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Article

Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2006

Labelle-Dumais Cassandre, Jacob-Wagner Mariève, Paré Jean-Francois, Bélanger Luc, Dufort Daniel

Abstract excerpt

NR5A2, also known as liver receptor homologue 1 (LRH-1) and fetoprotein transcription factor (FTF), is an orphan nuclear receptor involved in the regulation of cholesterol metabolism and steroidogenesis in the adult. NR5A2 was also shown to be expressed during early mouse embryogenesis. Consistent with its early expression pattern, a targeted disruption of this gene leads to embryonic lethality around the...

Topics

Animals
Base Sequence
Body Patterning
Chimera
DNA Primers
Embryonic Development
Endoderm
Female
GATA4 Transcription Factor
Gastrula
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Markers

Hepatocyte Nuclear Factor 4

Male

Mesoderm

Mice

Mice, Knockout

Phenotype

Source

Open in PubMed

Identifiers

PMID: 17075876
DOI: 10.1002/dvdy.20996

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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