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Article

Double-hit B-cell lymphomas

1 Dec 2010

Abstract excerpt

In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. An intriguing subset is formed by the so-called double- hit (DH) lymphomas that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another recurrent breakpoint, mainly a t(14;18)(q32;q21) involving BCL2. Recently, these lymphomas have received increased attention, which...

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PMID: 21119107
DOI: 10.1182/blood-2010-09-297879

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