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Article

MYC/BCL2 double-hit high-grade B-cell lymphoma.

Advances in anatomic pathology - 1 Sept 2013

Li Shaoying, Lin Pei, Young Ken H, Kanagal-Shamanna Rashmi, Yin C Cameron, Medeiros L Jeffrey

Abstract excerpt

Double-hit lymphoma (DHL) has been defined by others as a B-cell lymphoma with MYC/8q24 rearrangement in combination with a translocation involving another gene, such as BCL2, BCL3, or BCL6. The most common form of DHL has translocations involving MYC and BCL2, also known as MYC/BCL2 DHL. In recent years, a number of case series of MYC/BCL2 DHL have been published. Most cases of MYC/BCL2 DHL morphologically...

Topics

Biomarkers, Tumor
Cell Proliferation
Gene Rearrangement
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Karyotyping
Lymphoma, B-Cell
Mutation
Neoplasm Grading
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Prognosis

Proto-Oncogene Proteins c-bcl-2

Proto-Oncogene Proteins c-myc

Translocation, Genetic

Source

Identifiers

PMID: 23939148
DOI: 10.1097/PAP.0b013e3182a289f2

Genes

BCL2
MYC
BCL3
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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