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Article

Double hit lymphoma: from biology to therapeutic implications.

Expert review of hematology - 1 Jul 2016

Burotto Mauricio, Berkovits Alejandro, Dunleavy Kieron

Abstract excerpt

INTRODUCTION: Diffuse large B-cell lymphoma (DLBCL) is a molecularly heterogeneous disease defined by different cellular origins and mechanisms of oncogenic activation. Approximately 10% of DLBCL cases harbor a MYC rearrangement and this has been associated with a more aggressive clinical course following standard therapy. AREAS COVERED: So-called 'double-hit lymphomas' (DHL) or 'triple hit lymphomas' (THL) occur...

Read the complete abstract on PubMed

Topics

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Share to Drug Discovery
Share to Genes, myc
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma

Share to Lymphoma, Large B-Cell, Diffuse

Share to Oncogenes

Share to Proto-Oncogene Proteins c-bcl-2

Share to Translocation, Genetic

Source

Identifiers

PMID: 27166590
DOI: 10.1080/17474086.2016.1182858

Genes

MYC
BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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