Article
Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas.
The American journal of surgical pathology - 1 Mar 2013
Pillai Raju K, Sathanoori Malini, Van Oss Stephen Branden, Swerdlow Steven H
Abstract excerpt
Double-hit (DH) lymphomas with MYC and either BCL2 (DH-BCL2/MYC) or BCL6 (DH-BCL6/MYC) rearrangements are considered very aggressive, many of which are now included in the category B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (DLBCL/BL). However, data describing the DH cases are largely based on DH-BCL2/MYC cases. To better...
Topics
- Aged
- Aged, 80 and over
- DNA-Binding Proteins
- Female
- Flow Cytometry
- Genes, bcl-2
- Genes, myc
- Humans
- Immunohistochemistry
- Immunophenotyping
- In Situ Hybridization, Fluorescence
- Lymphoma, B-Cell
- Male
- Middle Aged