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Article

Arctic mutant Aβ40 aggregates on α7 nicotinic acetylcholine receptors and inhibits their functions.

Journal of neurochemistry - 1 Dec 2014

Ju Ye, Asahi Toru, Sawamura Naoya

Abstract excerpt

Amyloid β protein (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD). Point mutations within the Aβ sequence associated with familial AD (FAD) are clustered around the central hydrophobic core of Aβ. Several types of mutations within the Aβ sequence have been identified, and the 'Arctic' mutation (E22G) has a purely cognitive phenotype typical of AD. Previous studies have shown that the...

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Identifiers

PMID: 25059095
DOI: 10.1111/jnc.12837

Genes

CHRNA7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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