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Article

Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study.

Experimental lung research - 1 Sept 2014

Silveyra Patricia, Chroneos Zissis C, DiAngelo Susan L, Thomas Neal J, Noutsios Georgios T, Tsotakos Nikolaos, Howrylak Judie A, Umstead Todd M, Floros Joanna

Abstract excerpt

Human surfactant protein A (SP-A) plays an important role in surfactant metabolism and lung innate immunity. SP-A is synthesized and secreted by alveolar type II (ATII) cells, one of the two cell types of the distal lung epithelium (ATII and ATI). We have shown that miRNA interactions with sequence polymorphisms on the SP-A mRNA 3'UTRs mediate differential expression of SP-A1 and SP-A2 gene variants in vitro. In...

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Identifiers

PMID: 25058539
DOI: 10.3109/01902148.2014.929757
PMCID: PMC4197128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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