Article
Human surfactant protein A (SP-A) variants: why so many, why such a complexity?
Swiss medical weekly - 24 Feb 2001
Floros J
Abstract excerpt
Human surfactant protein A (SP-A) exhibits extensive complexity at several levels: genetic, transcript (splicing), protein, and composition and size of protein oligomers. Its multiple and important roles in innate host defense, regulation of inflammation, and in aspects of pulmonary surfactant may have necessitated such a complexity from an evolutionary point of view. Moreover, understanding of such a complexity...
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