Article
An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression.
Molecular and cellular biochemistry - 1 Jul 2000
Kaytor E N, Qian J, Towle H C, Olson L K
Abstract excerpt
Transcription of the L-type pyruvate kinase (L-PK) and S14 genes is induced in hepatocytes in response to increased glucose metabolism. The regulatory sequences of these genes responsible for induction by glucose have been mapped to related E-box containing motifs in the promoters. Similarly, L-PK promoter activity is stimulated in a differentiated pancreatic beta-cell line, INS-1, in response to elevated...
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