Article
Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.
The Journal of biological chemistry - 10 Feb 1995
Lefrançois-Martinez A M, Martinez A, Antoine B, Raymondjean M, Kahn A
Abstract excerpt
L-type pyruvate kinase (L-PK) gene transcription is induced by glucose through its glucose response element (GlRE) composed of two degenerated E boxes able to bind in vitro ubiquitous upstream stimulator factor (USF) proteins. Here we demonstrate in vivo, by transient transfections in hepatoma cells, that (i) native USF proteins synthesized from expression vectors can act as transactivators of the L-PK promoter...
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