Article
Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.
The Journal of biological chemistry - 10 Feb 1995
Lefrançois-Martinez A M, Martinez A, Antoine B, Raymondjean M, Kahn A
Abstract excerpt
L-type pyruvate kinase (L-PK) gene transcription is induced by glucose through its glucose response element (GlRE) composed of two degenerated E boxes able to bind in vitro ubiquitous upstream stimulator factor (USF) proteins. Here we demonstrate in vivo, by transient transfections in hepatoma ce...
Topics
- Base Sequence
- DNA-Binding Proteins
- Enzyme Activation
- Glucose
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Promoter Regions, Genetic
- Pyruvate Kinase
- Transcription Factors