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Article

Genetic association between CDKN2B/CDKN2B-AS1 gene polymorphisms with primary glaucoma in a North Indian cohort: an original study and an updated meta-analysis.

BMC medical genomics - 4 Jan 2021

Thakur Nanamika, Kupani Manu, Mannan Rashim, Pruthi Archna, Mehrotra Sanjana

Abstract excerpt

BACKGROUND: Variants in CDKN2B/CDKN2B-AS1 have been reported to modulate glaucoma risk in several GWAS across different populations. CDKN2B/CDKN2A encodes tumor suppressor proteins p16INK4A/p15INK4B which influences cell proliferation/senescence in RGCs, the degeneration of which is a risk factor for glaucoma. CDKN2B-AS1 codes a long non-coding RNA in antisense direction and is involved in influencing nearby...

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PMID: 33397358
DOI: 10.1186/s12920-020-00855-1
PMCID: PMC7780652

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