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Article

Conserved residues of the human mitochondrial holocytochrome c synthase mediate interactions with heme.

Biochemistry - 19 Aug 2014

Babbitt Shalon E, San Francisco Brian, Bretsnyder Eric C, Kranz Robert G

Abstract excerpt

C-type cytochromes are distinguished by the covalent attachment of a heme cofactor, a modification that is typically required for its subsequent folding, stability, and function. Heme attachment takes place in the mitochondrial intermembrane space and, in most eukaryotes, is mediated by holocytochrome c synthase (HCCS). HCCS is the primary component of the eukaryotic cytochrome c biogenesis pathway, known as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25054239
DOI: 10.1021/bi500704p
PMCID: PMC4139152

Genes

HCCS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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