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Article

Engineered holocytochrome c synthases that biosynthesize new cytochromes c.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2017

Mendez Deanna L, Babbitt Shalon E, King Jeremy D, D'Alessandro John, Watson Michael B, Blankenship Robert E, Mirica Liviu M, Kranz Robert G

Abstract excerpt

Cytochrome c (cyt c), required for electron transport in mitochondria, possesses a covalently attached heme cofactor. Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a...

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PMID: 28196881
DOI: 10.1073/pnas.1615929114
PMCID: PMC5338485

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HCCS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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