Article
Verification of wild-type EGFR status in non-small cell lung carcinomas using a mutant-enriched PCR on selected cases.
The Journal of molecular diagnostics : JMD - 1 Sept 2014
Chen Yi-Lin, Lu Cheng-Chan, Yang Shu-Ching, Su Wen-Pin, Lin Ya-Lan, Chen Wan-Li, Huang Wenya, Su Wu-Chou, Chow Nan-Haw, Ho Chung-Liang
Abstract excerpt
EGFR genotyping is required for targeted therapy of lung adenocarcinoma. Because a false-negative result might prevent a patient from receiving appropriate targeted therapies, it is desirable to recheck equivocal results of EGFR genotyping. A cohort of 346 lung cancers was tested with a commercial kit for EGFR mutations; nine of the cases had upward real-time amplification curves at late cycles. They were also...
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