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Article

An evaluation study of EGFR mutation tests utilized for non-small-cell lung cancer in the diagnostic setting.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 2012

Goto K, Satouchi M, Ishii G, Nishio K, Hagiwara K, Mitsudomi T, Whiteley J, Donald E, McCormack R, Todo T

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) mutation is predictive for the efficacy of EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer (NSCLC) treatment. We evaluated the performance, sensitivity, and concordance between five EGFR tests. MATERIALS AND METHODS: DNA admixtures (n = 34; 1%-50% mutant plasmid DNA) and samples from NSCLC patients [116 formalin-fixed paraffin-embedded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22776705
DOI: 10.1093/annonc/mds121

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EGFR

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