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Article

Adiposity significantly modifies genetic risk for dyslipidemia.

Journal of lipid research - 1 Nov 2014

Cole Christopher B, Nikpay Majid, Lau Paulina, Stewart Alexandre F R, Davies Robert W, Wells George A, Dent Robert, McPherson Ruth

Abstract excerpt

Recent genome-wide association studies have identified multiple loci robustly associated with plasma lipids, which also contribute to extreme lipid phenotypes. However, these common genetic variants explain <12% of variation in lipid traits. Adiposity is also an important determinant of plasma lipoproteins, particularly plasma TGs and HDL cholesterol (HDLc) concentrations. Thus, interactions between genes and...

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Share to Adiposity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

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Share to Polymorphism, Single Nucleotide

Share to Triglycerides

Source

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Identifiers

PMID: 25225679
DOI: 10.1194/jlr.P052522
PMCID: PMC4617143

Genes

APOA5
CETP
GALNT2
GCKR
LIPG
LPL
PLTP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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