Article
Probing treatment response of glutaminolytic prostate cancer cells to natural drugs with hyperpolarized [5-(13) C]glutamine.
Magnetic resonance in medicine - 1 Jun 2015
Canapè Carolina, Catanzaro Giuseppina, Terreno Enzo, Karlsson Magnus, Lerche Mathilde Hauge, Jensen Pernille Rose
Abstract excerpt
PURPOSE: The correlation between glutamine metabolism and oncogene expression in cancers has led to a renewed interest in the role of glutamine in cancer cell survival. Hyperpolarized [5-(13) C]glutamine is evaluated as a potential biomarker for noninvasive metabolic measurements of drug response in prostate cancer cells. METHODS: Hyperpolarized [5-(13) C]glutamine is used to measure glutamine metabolism in two...
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