Article
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014
Viola-Villegas Nerissa Therese, Carlin Sean D, Ackerstaff Ellen, Sevak Kuntal K, Divilov Vadim, Serganova Inna, Kruchevsky Natalia, Anderson Michael, Blasberg Ronald G, Andreev Oleg A, Engelman Donald M, Koutcher Jason A, Reshetnyak Yana K, Lewis Jason S
Abstract excerpt
Generally, solid tumors (>400 mm(3)) are inherently acidic, with more aggressive growth producing greater acidity. If the acidity could be targeted as a biomarker, it would provide a means to gauge the pace of tumor growth and degree of invasiveness, as well as providing a basis for predicting responses to pH-dependent chemotherapies. We have developed a (64)Cu pH (low) insertion peptide (pHLIP) for targeting,...
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