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Inhibition of guanosine monophosphate synthetase ( GMPS ) blocks glutamine metabolism and prostate cancer growth

26 Mar 2021

Abstract excerpt

Abstract Glutamine is a critical nutrient in cancer; however, its contribution to purine metabolism in prostate cancer has not previously been determined. Guanosine monophosphate synthetase (GMPS) acts in the de novo purine biosynthesis pathway, utilizing a glutamine amide to synthesize the guanine nucleotide. This study demonstrates that GMPS mRNA expression correlates with Gleason score in prostate cancer...

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PMID: 33768538
DOI: 10.1002/path.5665

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