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Article

Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer

15 May 2017

Abstract excerpt

Abstract Despite the known importance of androgen receptor (AR) signaling in prostate cancer, the processes downstream of AR that drive disease development and progression remain poorly understood. This knowledge gap has thus limited the ability to treat cancer. Here, it is demonstrated that androgens increase the metabolism of glutamine in prostate cancer cells. This metabolism was required for maximal cell...

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PMID: 28507054
DOI: 10.1158/1541-7786.mcr-16-0480

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