Selphi, a tool for improving genotype imputation accuracy.

Abstract excerpt

Genotype imputation is a powerful tool for inferring missing genotype data in large-scale genetic studies. Over the last two decades, multiple imputation algorithms have been developed, steadily improving in speed and overall accuracy. However, accurate imputation of rare and infrequent variants remains a challenge, largely because existing methods rely on local haplotype matching within genomic windows and do...

Topics

• Genome-Wide Association Study
• Humans
• Algorithms
• Genotype
• Haplotypes
• Polymorphism, Single Nucleotide