Article
Applying polygenic risk scores to postpartum depression.
Archives of women's mental health - 1 Dec 2014
Byrne Enda M, Carrillo-Roa Tania, Penninx Brenda W J H, Sallis Hannah M, Viktorin Alexander, Chapman Brett, Henders Anjali K, Pergadia Michele L, Heath Andrew C, Madden Pamela A F, Sullivan Patrick F, Boschloo Lynn, van Grootheest Gerard, McMahon George, Lawlor Debbie A, Landén Mikael, Lichtenstein Paul, Magnusson Patrik K E, Evans David M, Montgomery Grant W, Boomsma Dorret I, Martin Nicholas G, Meltzer-Brody Samantha, Wray Naomi R
Abstract excerpt
The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis. We assembled a total cohort of 1,420 self-report cases of PPD and 9,473 controls with genome-wide genotypes from Australia, The Netherlands, Sweden and the UK. We estimated the total...
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