Article

Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration

2024-05-05

Abstract excerpt

Loss of select neuronal populations such as midbrain dopamine (DA) neurons is a pathological hallmark of Parkinson’s disease (PD). The small neuronal protein α-synuclein has been related both genetically and neuropathologically to PD, yet how it contributes to selective vulnerability remains elusive. Here, we describe the generation of a novel adeno-associated viral vector (AAV) for Cre-dependent overexpression of...

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Literature Corpus work: 1e473abf-a181-5c8c-a178-d4f155c25ce0
DOI: 10.1101/2024.05.03.592188

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