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Article

Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma.

PloS one - 1 Jan 2014

Cornelissen Robin, Lievense Lysanne A, Maat Alexander P, Hendriks Rudi W, Hoogsteden Henk C, Bogers Ad J, Hegmans Joost P, Aerts Joachim G

Abstract excerpt

HYPOTHESIS: The tumor micro-environment and especially the different macrophage phenotypes appear to be of great influence on the behavior of multiple tumor types. M1 skewed macrophages possess anti-tumoral capacities, while the M2 polarized macrophages have pro-tumoral capacities. We analyzed if the macrophage count and the M2 to total macrophage ratio is a discriminative marker for outcome after surgery in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25192022
DOI: 10.1371/journal.pone.0106742
PMCID: PMC4156398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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