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Article

Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.

Molecular cancer research : MCR - 1 Nov 2014

Rothblum Katrina, Hu Qiyue, Penrod Yvonne, Rothblum Lawrence I

Abstract excerpt

UNLABELLED: The interface between the polymerase I-associated factor Rrn3 and the 43-kDa subunit of RNA polymerase I is essential to the recruitment of Pol I to the preinitiation complex on the rDNA promoter. In silico analysis identified an evolutionarily conserved 22 amino acid peptide within rpa43 that is both necessary and sufficient to mediate the interaction between rpa43 and Rrn3. This peptide inhibited...

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Identifiers

PMID: 25033839
DOI: 10.1158/1541-7786.MCR-14-0229
PMCID: PMC4233170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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