Article
Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.
European archives of psychiatry and clinical neuroscience - 1 Jun 2015
Nickl-Jockschat Thomas, Stöcker Tony, Krug Axel, Markov Valentin, Maximov Ivan I, Huang Ruiwang, Schneider Frank, Habel Ute, Eickhoff Simon B, Zerres Klaus, Nöthen Markus M, Rietschel Marcella, Jon Shah N, Treutlein Jens, Kircher Tilo
Abstract excerpt
G72 (syn. DAOA, D-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. Diffusion tensor imaging studies hint at changes in fiber tract integrity in both disorders. We aimed to investigate whether a G72 susceptibility haplotype causes changes in fiber tract integrity in young healthy subjects. We compared fractional anisotropy in 47 subjects that were either...
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