Article
The G72/G30 gene complex and cognitive abnormalities in schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2006
Goldberg Terry E, Straub Richard E, Callicott Joseph H, Hariri Ahmad, Mattay Venkata S, Bigelow Llewellyn, Coppola Richard, Egan Michael F, Weinberger Daniel R
Abstract excerpt
A recently discovered gene complex, G72/G30 (hereafter G72, but now termed DAOA), was found to be associated with schizophrenia and with bipolar disorder, possibly because of an indirect effect on NMDA neurotransmission. In principle, if G72 increases risk for psychosis by this mechanism, it might impact with greater penetrance those cortically based cognitive and neurophysiological functions associated with NMDA...
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