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Article

G Protein–Coupled Estrogen Receptor Regulates Mammary Tumorigenesis and Metastasis

17 Jul 2014

Abstract excerpt

UNLABELLED: The role of 17β-estradiol (E2) in breast cancer development and tumor growth has traditionally been attributed exclusively to the activation of estrogen receptor-α (ERα). Although targeted inhibition of ERα is a successful approach for patients with ERα(+) breast cancer, many patients fail to respond or become resistant to anti-estrogen therapy. The discovery of the G protein-coupled estrogen receptor...

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PMID: 25030371
DOI: 10.1158/1541-7786.mcr-14-0128-t

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