Article
Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.
Recent progress in hormone research - 1 Jan 1996
Korach K S, Couse J F, Curtis S W, Washburn T F, Lindzey J, Kimbro K S, Eddy E M, Migliaccio S, Snedeker S M, Lubahn D B, Schomberg D W, Smith E P
Abstract excerpt
The estrogen receptor (ER) is thought to play a crucial role in the regulation of many life processes, including development, reproduction and normal physiology. Because there have been no known mutations of the estrogen receptor in normal tissue of humans and animals, its presence and tissue distribution is thought to be essential for survival. Using the techniques of homologous recombination, we have disrupted...
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