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Article

G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis.

Cancer letters - 28 Nov 2016

Wei Tao, Chen Wei, Wen Liang, Zhang Jian, Zhang Qi, Yang Jiaqi, Liu Hao, Chen Bryan Wei, Zhou Yue, Feng Xinhua, Yang Qi, Bai Xueli, Liang Tingbo

Abstract excerpt

G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC). Our data show GPER knockout in a diethylnitrosamine (DEN)-induced mouse tumor model significantly accelerated liver tumorigenesis, accompanied by enhanced immune cell infiltration, fibrosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27594673
DOI: 10.1016/j.canlet.2016.08.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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