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Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease model

29 Oct 2024

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) have emerged as promising candidates for immune modulation in various diseases that are associated with dysregulated immune responses like Graft-versus-Host-Disease (GVHD). MSCs are pleiotropic and the fate of MSCs following administration is a major determinant of their therapeutic efficacy. METHODS: Human MSCs were derived from bone marrow (BM) and Wharton's Jelly (WJ)...

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PMID: 39468660
DOI: 10.1186/s13287-024-03947-2

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