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Article

p53 negatively regulates the osteogenic differentiation of vascular smooth muscle cells in mice with chronic kidney disease.

Cardiovascular journal of Africa - 12 Jul 2012

Li K L, Chen J, Li Z H, Zhao L, He Y N

Abstract excerpt

AIM: To investigate the osteogenic differentiation of vascular smooth muscle cells (VSMCs) in mice with chronic kidney disease (CKD) and to evaluate the effects of p53 on the osteogenic differentiation of the VSMCs. METHODS: Experimental models of CKD-associated vascular calcification generated by five-sixth (5/6) nephrectomy (Nx) and a high-phosphate (HP) diet were used in p53+/+ and p53-/- mice. Following 5/6...

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Identifiers

PMID: 22143460
DOI: 10.5830/CVJA-2011-069
PMCID: PMC3734878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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