Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Expression of <i>CAI2</i> , a <i>9p21</i> -Embedded Long Noncoding RNA, Contributes to Advanced-Stage Neuroblastoma

14 Jul 2014

Abstract excerpt

Neuroblastoma is a pediatric cancer with significant genomic and biologic heterogeneity. p16 and ARF, two important tumor-suppressor genes on chromosome 9p21, are inactivated commonly in most cancers, but paradoxically overexpressed in neuroblastoma. Here, we report that exon γ in p16 is also part of an undescribed long noncoding RNA (lncRNA) that we have termed CAI2 (CDKN2A/ARF Intron 2 lncRNA). CAI2 is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Neuroblastoma Research and Treatments
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25028366
DOI: 10.1158/0008-5472.can-13-3447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Expression of <i>CAI2</i> , a <i>9p21</i> -Embedded Long Noncoding RNA, Contributes to Advanced-Stage NeuroblastomaPMID 25028366Read ↗

Loss of <i>p16INK4a</i> in neuroblastoma cells induces shift to an immature state with mesenchymal characteristics and increases sensitivity to EGFR inhibitorsSemantic proximity Read ↗

PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axisSemantic proximity Read ↗

Two opposing gene expression patterns within <i>ATRX</i> aberrant neuroblastomaSemantic proximity Read ↗

Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.Semantic proximity Read ↗

microRNA Signature and Expression of <i>Dicer</i> and <i>Drosha</i> Can Predict Prognosis and Delineate Risk Groups in NeuroblastomaSemantic proximity Read ↗

Clinically significant copy number alterations and complex rearrangements of <i>MYB</i> and <i>NFIB</i> in head and neck adenoid cystic carcinomaSemantic proximity Read ↗

RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma.Semantic proximity Read ↗

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.Semantic proximity Read ↗

The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastomaSemantic proximity Read ↗

The p16 (CDKN2A) gene is involved in the growth of neuroblastoma cells and its expression is associated with prognosis of neuroblastoma patientsSemantic proximity Read ↗

<i>CAMTA1</i> , a 1p36 Tumor Suppressor Candidate, Inhibits Growth and Activates Differentiation Programs in Neuroblastoma CellsSemantic proximity Read ↗

Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.