Clinically significant copy number alterations and complex rearrangements of <i>MYB</i> and <i>NFIB</i> in head and neck adenoid cystic carcinoma

Abstract excerpt

Adenoid cystic carcinoma (ACC) of the head and neck is a malignant tumor with poor long-term prognosis. Besides the recently identified MYB-NFIB fusion oncogene generated by a t(6;9) translocation, little is known about other genetic alterations in ACC. Using high-resolution, array-based comparative genomic hybridization, and massively paired-end sequencing, we explored genomic alterations in 40 frozen ACCs....

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