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Article

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.

Cancer research - 1 Aug 2015

Russell Mike R, Penikis Annalise, Oldridge Derek A, Alvarez-Dominguez Juan R, McDaniel Lee, Diamond Maura, Padovan Olivia, Raman Pichai, Li Yimei, Wei Jun S, Zhang Shile, Gnanchandran Janahan, Seeger Robert, Asgharzadeh Shahab, Khan Javed, Diskin Sharon J, Maris John M, Cole Kristina A

Abstract excerpt

Chromosome 6p22 was identified recently as a neuroblastoma susceptibility locus, but its mechanistic contributions to tumorigenesis are as yet undefined. Here we report that the most highly significant single-nucleotide polymorphism (SNP) associations reside within CASC15, a long noncoding RNA that we define as a tumor suppressor at 6p22. Low-level expression of a short CASC15 isoform (CASC15-S) associated highly...

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Share to Cell Differentiation
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 6

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Neuroblastoma

Share to Reproducibility of Results

Share to RNA, Long Noncoding

Source

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Identifiers

PMID: 26100672
DOI: 10.1158/0008-5472.CAN-14-3613
PMCID: PMC4526355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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