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Article

Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Cheung Arthur Kwok Leung, Lung Hong Lok, Ko Josephine Mun Yee, Cheng Yue, Stanbridge Eric J, Zabarovsky Eugene R, Nicholls John M, Chua Daniel, Tsao Sai Wah, Guan Xin-Yuan, Lung Maria Li

Abstract excerpt

Chromosome 14 allelic loss is common in nasopharyngeal carcinoma (NPC) and may reflect essential tumor suppressor gene loss in tumorigenesis. An intact chromosome 14 was transferred to an NPC cell line using a microcell-mediated chromosome transfer approach. Microcell hybrids (MCHs) containing intact exogenously transferred chromosome 14 were tumor suppressive in athymic mice, demonstrating that intact chromosome...

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Share to Cell Line, Transformed
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Gene Transfer Techniques

Share to Nasopharyngeal Neoplasms

Share to Neoplasms, Experimental

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 19667180
DOI: 10.1073/pnas.0900198106
PMCID: PMC2732794

Genes

MIPOL1
FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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