Article

Doxepin Drug-Drug and Drug-Gene Interactions: Clinical Implications and Mechanistic Insights

2025-05-15

Abstract excerpt

<h4>Background: </h4> /Objectives: Initially approved for the treatment of major depressive disorder, doxepin’s clinical applications have expanded to include pruritus and insomnia due to its receptor-specific activities at varying doses. This narrative review highlights the pharmacokinetics of doxepin, emphasizing its metabolism via CYP2D6 and CYP2C19 enzymes and the clinical implication of enzyme inhibitio...

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Literature Corpus work: 5f881acb-e4e0-5464-a9b9-1c0d00c8ac3b
DOI: 10.20944/preprints202505.1010.v1

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