Article
In Vitro Reaction Phenotyping and Projection of Drug Interactions Mediated by Cytochrome P450 Enzymes for Central Nervous System Drugs as Victims: Implications for Safety in Vulnerable Populations.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2026
Palacharla Veera Raghava Chowdary, Nirogi Ramakrishna, Kumar Nitesh, Jayarajan Pradeep, Pantangi Hanumanth Rao, Petlu Surendra, Nandakumar Krishnadas
Abstract excerpt
Accurate prediction of cytochrome P450-mediated victim drug-drug interactions (DDIs) is critical for the safe use of central nervous system (CNS) drugs, particularly in populations at high risk of polypharmacy. This study evaluated the utility and limitations of in vitro human liver microsomal data for predicting victim DDIs of CNS compounds metabolized by CYP1A2, CYP2B6, CYP2D6, and CYP3A4. Reaction phenotyping...
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