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Article

Directed evolution of an LBP/CD14 inhibitory peptide and its anti-endotoxin activity.

PloS one - 1 Jan 2014

Fang Li, Xu Zhi, Wang Guan-song, Ji Fu-yun, Mei Chun-xia, Liu Juan, Wu Guo-ming

Abstract excerpt

BACKGROUND: LPS-binding protein (LBP) and its ligand CD14 are located upstream of the signaling pathway for LPS-induced inflammation. Blocking LBP and CD14 binding might prevent LPS-induced inflammation. In previous studies, we obtained a peptide analog (MP12) for the LBP/CD14 binding site and showed that this peptide analog had anti-endotoxin activity. In this study, we used in vitro directed evolution for this...

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Share to Acute-Phase Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharide Receptors

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Source

Open in PubMed Open full text

Identifiers

PMID: 25025695
DOI: 10.1371/journal.pone.0101406
PMCID: PMC4098906

Genes

LBP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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