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Article

Variants in SNAP25 are targets of natural selection and influence verbal performances in women.

Cellular and molecular life sciences : CMLS - 1 May 2012

Cagliani Rachele, Riva Stefania, Marino Cecilia, Fumagalli Matteo, D'Angelo Maria Grazia, Riva Valentina, Comi Giacomo P, Pozzoli Uberto, Forni Diego, Cáceres Mario, Bresolin Nereo, Clerici Mario, Sironi Manuela

Abstract excerpt

Descriptions of genes that are adaptively evolving in humans and that carry polymorphisms with an effect on cognitive performances have been virtually absent. SNAP25 encodes a presynaptic protein with a role in regulation of neurotransmitter release. We analysed the intra-specific diversity along SNAP25 and identified a region in intron 1 that shows signatures of balancing selection in humans. The estimated TMRCA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22193912
DOI: 10.1007/s00018-011-0896-y
PMCID: PMC11114840

Genes

SNAP25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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