Article
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2014
Xiong Shunbin, Tu Huolin, Kollareddy Madhusudhan, Pant Vinod, Li Qin, Zhang Yun, Jackson James G, Suh Young-Ah, Elizondo-Fraire Ana C, Yang Peirong, Chau Gilda, Tashakori Mehrnoosh, Wasylishen Amanda R, Ju Zhenlin, Solomon Hilla, Rotter Varda, Liu Bin, El-Naggar Adel K, Donehower Lawrence A, Martinez Luis Alfonso, Lozano Guillermina
Abstract excerpt
p53(R172H/+) mice inherit a p53 mutation found in Li-Fraumeni syndrome and develop metastatic tumors at much higher frequency than p53(+/-) mice. To explore the mutant p53 metastatic phenotype, we used expression arrays to compare primary osteosarcomas from p53(R172H/+) mice with metastasis to osteosarcomas from p53(+/-) mice lacking metastasis. For this study, 213 genes were differentially expressed with a P...
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