Article
Does TP53 mutation promote ovarian cancer metastasis to omentum by regulating lipid metabolism?
Medical hypotheses - 1 Oct 2013
Hu Jing, Liu Zhiqiang, Wang Xipeng
Abstract excerpt
TP53 (Tumor Protein 53, previously known as p53) is probably the best known of all tumor suppressor genes, and is mutated in nearly all (96%) high-grade serous ovarian cancer (HGS-OvCa), which is the most common histopathological type of epithelial ovarian cancer (EOC). Recently, TP53 is found to involve in regulating cell metabolic pathways besides its classical tumor suppressive functions. In addition, emerging...
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