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Article

PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.

Journal of cellular and molecular medicine - 1 Nov 2020

Xia Wei, Bai Hansong, Deng Ying, Yang Yi

Abstract excerpt

PLA2G16 is a member of the phospholipase family that catalyses the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. In the current study, we explored the functional role of PLA2G16 in pancreatic adenocarcinoma (PAAD) and the genetic/epigenetic alterations leading to its dysregulation. Bioinformatic analysis was performed using data from The Cancer Genome Atlas...

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Identifiers

PMID: 32985124
DOI: 10.1111/jcmm.15832
PMCID: PMC7686977

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