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Article

Genetic polymorphism and expression of HSF1 gene is significantly associated with breast cancer in Saudi females.

PloS one - 1 Jan 2018

Almotwaa Sahar, Elrobh Mohamed, AbdulKarim Huda, Alanazi Mohamed, Aldaihan Sooad, Shaik Jilani, Arafa Maha, Warsy Arjumand Sultan

Abstract excerpt

The transcription factor, heat shock factor 1 (HSF1), influences the expression of heat shock proteins as well as other activities like the induction of tumor suppressor genes, signal transduction pathway, and glucose metabolism. We hypothesized that single nucleotide polymorphisms (SNPs) in HSF1 gene might affect its expression or function which might have an influence on the development of breast cancer. The...

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Identifiers

PMID: 29494616
DOI: 10.1371/journal.pone.0193095
PMCID: PMC5832201

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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