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Article

Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice

11 Jul 2014

Abstract excerpt

INTRODUCTION: Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficking. The objective of the current study was to examine the function of syndecan-3 in joint inflammation by genetic deletion in mice and compare with other tissues....

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PMID: 25015005
DOI: 10.1186/ar4610

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